Novel Immunotherapy-based Cure Interventions

Type-I interferon modulation in vivo blocks SARS-CoV-2 replication and inflammation

Dual IL-10 and PD-1 blockade in SIVmac239 infected macaques promotes sustained virologic control in the absence of ART

Baricitinib lowers inflammation and pathology in SARS-CoV-2-infected rhesus macaques

Therapies targeting tissue inflammation and viral persistence

FTY720 limits T follicular helper cell infection in lymphoid sites of SIV persistence

PD-1 and CTLA-4 blockage in macaques induces T-cell expansion and SIV reactivation

Immune-based interventions targeting inflammation and viral persistence

IL-21 reduces inflammation and virus persistence in ART-treated SIV-infected macaques

CCR6+ and CD161+ CD4 T cell loss contributes to the pathogenesis of SIV infection in rhesus macaques